| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 13/09/25 16:30 | Ajax Amsterdam | PEC Zwolle | 3:1 |
| 13/09/25 18:45 | NEC Nijmwegen | PSV Eindhoven | 3:5 |
| 13/09/25 19:10 | Go Ahead Eagles Deventer | FC Volendam | 3:0 |
| 13/09/25 21:00 | FC Twente Enschede | NAC Breda | 2:2 |
| 13/09/25 21:00 | Feyenoord Rotterdam | SC Heerenveen | 1:0 |
| 14/09/25 12:15 | Excelsior Rotterdam | Sparta Rotterdam | -:- |
| 14/09/25 14:30 | Heracles Almelo | AZ Alkmaar | -:- |
| 14/09/25 14:30 | FC Utrecht | FC Groningen | -:- |
| 14/09/25 16:45 | Telstar | Fortuna Sittard | -:- |